Cheap Flights to Spain from 644 USD

Search Top Routes and Airfare Deals to Spain

USD

Panama City (PTY)to

Madrid (MAD)
28/10/2025 - 07/11/2025
From
644 USD
Viewed 16 hours ago
Round trip
Economy

Panama City (PTY)to

Bilbao (BIO)
13/11/2025 - 23/11/2025
From
687 USD
Viewed 1 day ago
Round trip
Economy

Panama City (PTY)to

Barcelona (BCN)
19/10/2025 - 21/11/2025
From
696 USD
Viewed 1 day ago
Round trip
Economy

Panama City (PTY)to

Alicante (ALC)
15/10/2025 - 21/10/2025
From
713 USD
Viewed 19 hours ago
Round trip
Economy

Panama City (PTY)to

Vigo (VGO)
25/10/2025 - 18/11/2025
From
846 USD
Viewed 1 day ago
Round trip
Economy

Panama City (PTY)to

Valencia (VLC)
10/11/2025 - 27/11/2025
From
848 USD
Viewed 18 hours ago
Round trip
Economy

Panama City (PTY)to

Palma de Mallorca (PMI)
25/09/2025 - 07/10/2025
From
1.071 USD
Viewed 1 day ago
Round trip
Economy

Panama City (PTY)to

Malaga (AGP)
18/09/2025 - 26/09/2025
From
1.211 USD
Viewed 1 day ago
Round trip
Economy

Panama City (PTY)to

Tenerife (TFN)
08/09/2025 - 21/10/2025
From
1.851 USD
Viewed 22 hours ago
Round trip
Economy

*Prices have been available for round-trip flights within the last 48 hours and may not be currently available. Additional baggage fees and fees for other optional services may apply. Other terms and conditions may apply.

Search Top Routes and Airfare Deals to Spain

USD
Search Top Routes and Airfare Deals to Spain
From
To
Trip type
Dates
Price
Panama City (PTY)Madrid (MAD)Round trip
|
Economy
28/10/2025 - 07/11/2025

From

644 USD

Viewed 16 hours ago

Panama City (PTY)Madrid (MAD)Round trip
|
Economy
20/10/2025 - 07/11/2025

From

645 USD

Viewed 1 day ago

Panama City (PTY)Bilbao (BIO)Round trip
|
Economy
13/11/2025 - 23/11/2025

From

687 USD

Viewed 1 day ago

Panama City (PTY)Barcelona (BCN)Round trip
|
Economy
19/10/2025 - 21/11/2025

From

696 USD

Viewed 1 day ago

Panama City (PTY)Bilbao (BIO)Round trip
|
Economy
04/11/2025 - 14/11/2025

From

712 USD

Viewed 1 day ago

Panama City (PTY)Alicante (ALC)Round trip
|
Economy
15/10/2025 - 21/10/2025

From

713 USD

Viewed 19 hours ago

Panama City (PTY)Barcelona (BCN)Round trip
|
Economy
04/11/2025 - 20/11/2025

From

732 USD

Viewed 20 hours ago

Panama City (PTY)Vigo (VGO)Round trip
|
Economy
25/10/2025 - 18/11/2025

From

846 USD

Viewed 1 day ago

Panama City (PTY)Valencia (VLC)Round trip
|
Economy
10/11/2025 - 27/11/2025

From

848 USD

Viewed 18 hours ago

Panama City (PTY)Vigo (VGO)Round trip
|
Economy
28/11/2025 - 15/01/2026

From

914 USD

Viewed 1 day ago

Panama City (PTY)Valencia (VLC)Round trip
|
Economy
08/10/2025 - 03/11/2025

From

1.006 USD

Viewed 1 day ago

Panama City (PTY)Malaga (AGP)Round trip
|
Economy
19/12/2025 - 10/01/2026

From

1.278 USD

Viewed 1 day ago

Panama City (PTY)Malaga (AGP)Round trip
|
Economy
02/11/2025 - 11/11/2025

From

1.288 USD

Viewed 16 hours ago

*Prices have been available for round-trip flights within the last 48 hours and may not be currently available. Additional baggage fees and fees for other optional services may apply. Other terms and conditions may apply.

Compare Cheap Flights to Spain

Visit Spain

A popular European destination, Spain offers glorious beaches and islands, delicious gastronomy, beautiful countryside, historic cities, fantastic shopping and a rich culture and heritage. Perfect for family vacations, couples seeking romance, fun-loving friends and adventurous solo travellers, Spain offers something for all. Book your flights on Air Europa’s official website and fly to Spain in comfort for less.

Top Places to Visit in Spain

  • Enjoy a chic city break in Madrid (MAD), with renowned art galleries, legendary football clubs, modern malls, interesting architecture and a pulsating night scene.
  • Marvel at Gaudi’s architectural gems in Barcelona, including the magnificent Sagrada Familia and the quirky Parc Güell. Relax on the beach, experience Catalonian culture, and hop between the city’s many nightclubs.
  • Bilbao’s claim to fame is the striking Guggenheim Museum, while the Alhambra is one of Granada’s crowning jewels.
  • Visit the birthplace of paella and combine historic sightseeing with sunny beach life in Valencia.
  • More cities you should fly to in Spain include A Coruña (LCG), Alicante (ALC), Almeria (LEI), Asturias (OVD), Granada (GRX), Malaga (AGP), Melilla (MLN), Salamanca (SLM), Santa Cruz de la Palma (SPC), Santiago de Compostela (SCQ), Zaragoza (ZAZ), Seville (SVQ), Valladolid (VLL), and Vigo (VGO), among others.

Island Life: the Balearic Islands

The island of Ibiza (IBZ) is known for its youthful vibe and all-night parties, while Minorca (MAH) offers rugged landscapes and a tranquil vibe. Mallorca (PMI), the largest island in the archipelago, strikes a perfect balance, with stunning beaches, historic sites and plentiful activities.

Island Life: the Canaries

Each of the Canary Islands offers something different and exciting, from relaxing beaches to imposing landscapes and buzzing resorts. Book a flight to Tenerife (TCI), Lanzarote (ACE), Gran Canaria (LPA) or Fuerteventura (FUE) and discover your favourite island.

Food and Drink in Spain

When it comes to refuelling after a busy day of sightseeing, don’t be surprised if the restaurants don’t get busy until after 9:00 p.m. Meal times in Spain are different from in many other countries, with most Spaniards lunching between 1:30 p.m. and 3:00 p.m. and not dining until late into the evening! When the time does come to get some dinner, you’ll find that tapas is a delicious and economical option, with many bars giving the typical small dishes out for free when you buy drinks. If you aren’t drinking, you can still use this traditional Spanish way of dining to try several of those delicacies you’ve had your eye on.

Best Time to Visit Spain

While there is never a bad time to travel to Spain, spring and autumn are generally considered the best times to visit as temperatures are neither too hot nor too cold. Try to avoid European school holiday periods to beat the busiest crowds. December offers plenty of seasonal Christmas cheer. Avoid disappointment, secure your seat and book your flight to Spain today with Air Europa.

Explore Destinations in Spain