Lowest Priced Flights from Panama from 725 USD!
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Search Top Routes and Airfare Deals from Panama
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USD
Panama City (PTY)to
Madrid (MAD)03/22/2026 - 03/31/2026
From
725Â USD
Viewed 22 hours ago
Round trip
Economy
Panama City (PTY)to
Milan (MXP)09/24/2026 - 10/05/2026
From
764Â USD
Viewed 19 hours ago
Round trip
Economy
Panama City (PTY)to
Palma de Mallorca (PMI)02/10/2026 - 02/18/2026
From
802Â USD
Viewed 20 hours ago
Round trip
Economy
Panama City (PTY)to
Valencia (VLC)02/15/2026 - 02/22/2026
From
806Â USD
Viewed 20 hours ago
Round trip
Economy
Panama City (PTY)to
Paris (ORY)05/16/2026 - 05/30/2026
From
826Â USD
Viewed 5 hours ago
Round trip
Economy
Panama City (PTY)to
Vigo (VGO)01/26/2026 - 02/09/2026
From
842Â USD
Viewed 22 hours ago
Round trip
Economy
Panama City (PTY)to
Bilbao (BIO)01/28/2026 - 02/05/2026
From
844Â USD
Viewed 16 hours ago
Round trip
Economy
Panama City (PTY)to
Alicante (ALC)01/28/2026 - 02/05/2026
From
845Â USD
Viewed 22 hours ago
Round trip
Economy
Panama City (PTY)to
Barcelona (BCN)03/29/2026 - 04/12/2026
From
848Â USD
Viewed 11 hours ago
Round trip
Economy
Panama City (PTY)to
Amsterdam (AMS)06/03/2026 - 06/14/2026
From
867Â USD
Viewed 12 hours ago
Round trip
Economy
Panama City (PTY)to
Brussels (BRU)02/03/2026 - 02/23/2026
From
888Â USD
Viewed 10 hours ago
Round trip
Economy
Panama City (PTY)to
Lisbon (LIS)02/13/2026 - 02/23/2026
From
913Â USD
Viewed 4 hours ago
Round trip
Economy
Panama City (PTY)to
Zurich (ZRH)01/26/2026 - 02/12/2026
From
947Â USD
Viewed 13 hours ago
Round trip
Economy
Panama City (PTY)to
Tel Aviv (TLV)05/18/2026 - 05/31/2026
From
976Â USD
Viewed 13 hours ago
Round trip
Economy
Panama City (PTY)to
London (LGW)03/11/2026 - 03/20/2026
From
1.027Â USD
Viewed 12 hours ago
Round trip
Economy
Panama City (PTY)to
Porto (OPO)12/11/2025 - 02/21/2026
From
1.033Â USD
Viewed 21 hours ago
Round trip
Economy
Panama City (PTY)to
Malaga (AGP)12/15/2025 - 02/01/2026
From
1.048Â USD
Viewed 5 hours ago
Round trip
Economy
Panama City (PTY)to
Istanbul (IST)01/23/2026 - 03/28/2026
From
1.215Â USD
Viewed 1 hour ago
Round trip
Economy
Panama City (PTY)to
Paris (CDG)02/12/2026 - 03/05/2026
From
1.382Â USD
Viewed 13 hours ago
Round trip
Economy
Panama City (PTY)to
Frankfurt (FRA)12/31/2025 - 01/12/2026
From
1.489Â USD
Viewed 10 hours ago
Round trip
Economy
*Prices have been available for round-trip flights within the last 48 hours and may not be currently available. Additional baggage fees and fees for other optional services may apply. Other terms and conditions may apply.
Departing from Panama
Fly from Panama with Air Europa and get the best deal on your flight when you book through our official website. We offer flights to over 100 destinations around the world, including destinations in Europe and the Americas. Book your flight from Panama with Air Europa today and use our in-flight Wi-Fi to keep in touch with your friends and family.
Flights from Panama with Air Europa
Air Europa serves Panama via Panama City’s Tocumen International Airport (PTY), which lies 12.5 mi (20.2 km) north-east of the city centre. Call a taxi or book a ride on the shuttle to travel between the city centre and the airport. Travel time is 20 to 40 minutes, depending on the traffic.
- If you’ve squeezed in one last adventure before heading to the airport, stop by one of the airport lounges to enjoy a refreshing shower before your flight.
- Visit the currency exchange and ATM.
- Find last-minute souvenirs at the duty-free shops.
- Replenish your toiletries and medications at the pharmacy.
Earn miles and get special promotions when you join our Air Europa SUMA loyalty programme. Book your flight from Panama with Air Europa today and fly in comfort with our friendly staff.