Lowest Priced Flights from Panama from 670 USD!

Search Top Routes and Airfare Deals from Panama

USD

Panama City (PTY)to

Madrid (MAD)
11/21/2025 - 11/28/2025
From
670 USD
Viewed 52 minutes ago
Round trip
Economy

Panama City (PTY)to

Milan (MXP)
10/26/2025 - 01/25/2026
From
778 USD
Viewed 23 hours ago
Round trip
Economy

Panama City (PTY)to

A Coruna (LCG)
04/02/2026 - 04/30/2026
From
805 USD
Viewed 2 hours ago
Round trip
Economy

Panama City (PTY)to

Malaga (AGP)
06/07/2026 - 06/14/2026
From
809 USD
Viewed 5 hours ago
Round trip
Economy

Panama City (PTY)to

Barcelona (BCN)
02/11/2026 - 02/18/2026
From
827 USD
Viewed 14 hours ago
Round trip
Economy

Panama City (PTY)to

Brussels (BRU)
02/09/2026 - 02/15/2026
From
852 USD
Viewed 19 hours ago
Round trip
Economy

Panama City (PTY)to

Paris (ORY)
04/18/2026 - 04/28/2026
From
861 USD
Viewed 22 hours ago
Round trip
Economy

Panama City (PTY)to

Vigo (VGO)
12/16/2025 - 01/19/2026
From
922 USD
Viewed 1 hour ago
Round trip
Economy

Panama City (PTY)to

Porto (OPO)
12/30/2025 - 03/26/2026
From
925 USD
Viewed 15 hours ago
Round trip
Economy

Panama City (PTY)to

Alicante (ALC)
12/12/2025 - 01/30/2026
From
936 USD
Viewed 57 minutes ago
Round trip
Economy

Panama City (PTY)to

Palma de Mallorca (PMI)
12/24/2025 - 01/04/2026
From
961 USD
Viewed 1 hour ago
Round trip
Economy

Panama City (PTY)to

Amsterdam (AMS)
02/17/2026 - 02/28/2026
From
967 USD
Viewed 20 hours ago
Round trip
Economy

Panama City (PTY)to

Bilbao (BIO)
11/27/2025 - 12/09/2025
From
974 USD
Viewed 2 hours ago
Round trip
Economy

Panama City (PTY)to

Tenerife (TFN)
12/08/2025 - 04/22/2026
From
1.031 USD
Viewed 22 hours ago
Round trip
Economy

Panama City (PTY)to

Istanbul (IST)
03/15/2026 - 03/22/2026
From
1.071 USD
Viewed 13 hours ago
Round trip
Economy

Panama City (PTY)to

Frankfurt (FRA)
11/22/2025 - 12/07/2025
From
1.092 USD
Viewed 18 hours ago
Round trip
Economy

Panama City (PTY)to

London (LGW)
11/14/2025 - 11/22/2025
From
1.114 USD
Viewed 4 hours ago
Round trip
Economy

Panama City (PTY)to

Valencia (VLC)
12/19/2025 - 01/03/2026
From
1.181 USD
Viewed 15 hours ago
Round trip
Economy

Panama City (PTY)to

Lisbon (LIS)
11/01/2025 - 11/10/2025
From
1.299 USD
Viewed 17 hours ago
Round trip
Economy

Panama City (PTY)to

Paris (CDG)
01/16/2026 - 01/23/2026
From
1.358 USD
Viewed 3 hours ago
Round trip
Economy

*Prices have been available for round-trip flights within the last 48 hours and may not be currently available. Additional baggage fees and fees for other optional services may apply. Other terms and conditions may apply.

Search and Book Lowest airfares from Panama

Departing from Panama

Fly from Panama with Air Europa and get the best deal on your flight when you book through our official website. We offer flights to over 100 destinations around the world, including destinations in Europe and the Americas. Book your flight from Panama with Air Europa today and use our in-flight Wi-Fi to keep in touch with your friends and family.

Flights from Panama with Air Europa

Air Europa serves Panama via Panama City’s Tocumen International Airport (PTY), which lies 12.5 mi (20.2 km) north-east of the city centre. Call a taxi or book a ride on the shuttle to travel between the city centre and the airport. Travel time is 20 to 40 minutes, depending on the traffic.

  • If you’ve squeezed in one last adventure before heading to the airport, stop by one of the airport lounges to enjoy a refreshing shower before your flight.
  • Visit the currency exchange and ATM.
  • Find last-minute souvenirs at the duty-free shops.
  • Replenish your toiletries and medications at the pharmacy.

Earn miles and get special promotions when you join our Air Europa SUMA loyalty programme. Book your flight from Panama with Air Europa today and fly in comfort with our friendly staff.